Metronomic chemotherapy – is it the right choice for your pet?

This is a great explanation of a different type of chemotherapy method.

Growth Factors

In order for tumor cells to multiple and spread, they must develop their own blood supply through a process called angiogenesis. Angiogenesis inhibitor chemotherapy drugs work to stop or slow down this process, thereby controlling tumor growth. Metronomic chemotherapy is one example of angiogenesis inhibition treatment, which is becoming a popular treatment option for pets with cancer.

The definition of metronomic chemotherapy is variable, but usually refers to the continuous administration of low doses of oral chemotherapy drugs designed to target the endothelial cells lining the blood vessels supplying tumor cells.

When traditional cytotoxic chemotherapy is administered at maximally tolerated doses (MTD – see previous blog article entitled “Is the remedy for cancer worth the cure?”), death of the endothelial cells lining the blood vessels of tumor cells occurs first, followed by the death of the tumor cells. When we administer chemotherapy in this manner, we typically need to give…

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